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This is a seminal paper showing direct HLA multimer staining of in situ autoreactive T cells

For alternative deproteinization, cold trichloroacetic acid was added

New York: McGraw-Hill, 31113128

The enzyme glutathione reductase (GR) , utilizing the coenzyme NADPH, steps in to break the disulfide bond, recycling GSSG back into the active, reduced GSH state
Patients were randomized to receive pemetrexed 500 mg/m2 intravenously every 21 days or placebo until disease progression or intolerable toxicity
