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GSH can act as a molecular "gatekeeper" at multiple checkpoints of the necroptotic signaling cascade (Fig

By neutralising these free radicals, glutathione helps protect cells from damage, slowing down ageing and reducing the risk of chronic diseases such as heart disease, diabetes, and neurodegenerative disorders

These results suggest that mevalonate pathway regulation of GPX4 expression may also occur in patient tumors, raising the possibility that restoring mevalonate pathway activity could reverse the effects of statin treatment
