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Code was written in Python (version 3.9.16) using the sci-kit learn package ( and is publicly available at Data availability Data associated with this study can be requested for the authors and will be made available at MetabolomicsWorkbench: Code availability The code for the machine learning pipeline is publicly available at custom scripts will be made available at GitHub

Preparation of samples and transmission electron microscopy imaging were done as previously described [24]

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TB-500 does not suppress natural hormone production