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123 In an uncontrolled pilot study in 40 women with PCOS, the combination of myo-inositol and lipoic acid decreased male hormone levels, improved menstrual regularity, and reduced unwanted hair growth and BMI without affecting glucose or insulin parameters

J Biol Chem (2006) 281(50):3887993.10.1074/jbc.M608820200 92 AghazadehYRoneMBBlonderJYeXVeenstraTDHalesDBet alHormone-induced 14-3-3 adaptor protein regulates steroidogenic acute regulatory protein activity and steroid biosynthesis in MA-10 Leydig cells

For instance, Fluplatin@PEG-PE nanoparticles (FP NPs) can degrade mutp53 and trigger endoplasmic reticulum stress, alleviating resistance to cisplatin chemotherapy [99]

This phenomenon of adaptation to non-biological stressors was later found in various human/veterinary antibiotics

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