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[2] The MHRA Drug Safety Update (August 2022) advises healthcare professionals to consider testing vitamin B12 levels in patients taking metformin who develop symptoms of neuropathy or anaemia, and to consider periodic monitoring in those at risk of deficiency

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In animal and cell studies, blocking NNMT is theorized to raise intracellular NAD+ and activate SIRT1 , which researchers have linked to fat oxidation and preserved lean mass [1] [2]

Initially, injections are given daily or every other day for a week, then weekly for 12 months, followed by monthly maintenance