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In the mouse experiment of this cohort study, the investigators found that knocking out Keap1 resulted in the expression of Nrf2 target genes (such as GSH and NQO1), which supplemented the consumption of GSH in the oxidative stress response (Mohs et al., 2021)

Age-associated CD11c + B cells have also been observed to produce SS-related cytokines, including IL-1, IFN- and IL-10 (106)

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In the presence of BDZs, GABA interneurons are inhibited and no longer control (i.e., inhibit) DA neurons in the VTA (a process known as disinhibition), which results in increased activity of VTAs DAergic neurons

Additional contributing factors include increased expression of insulin-like growth factor 1 (IGF1) receptors, IGF1-binding protein (which protects IGF1 from proteolysis) in Purkinje cells [8], as well as upregulated mRNA expression of GLUT1 and GLUT3 [80]