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Statistical analysis Data were expressed as mean standard deviation (SD)

conducted a double-blind cross-over study of cyclobenzaprine at an evening dose of 10 or 30 mg and found a positive effect on tender points, anxiety, stiffness, and fatigue at the 10-mg dose, with fewer side effects than at the other dose [90]

Considering the multifactorial nature of TMAO generation, many strategies can be pursued to reduce the level of TMA/TMAO in patients with CVDs, such as lifestyle changes, use of antibiotics and functional foods, development of related inhibitors, and improvement of gut microbiota ( Supplementary Table 4 )

Thermo Fisher Scientific) in PBS for 30 min on ice