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doi: 10.1038/s41589-020-0472-6 197 ZouYHenryWSRicqELGrahamETPhadnisVVMaretichPet al
The MTHFR C677T polymorphism, folate, vitamin B12, and homocysteine: associations with depression
Another component that increases the danger level of these drugs is what is known as increased tolerance, sometimes the user needs more and more to achieve the desired effect, this can cause them to use more of the same drug, or turn to other more harmful drugs instead
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doi: 10.1016/S0300-483X(01)00471-1
