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17 The HPA axis is the most important neuroendocrine stress system, and the cortisol awakening response (CAR) is a core biomarker of HPA axis regulation

10.1016/j.pharmthera.2022.108165 Pharmacol Ther

In mammalian models, exposure has been reported as concentrations in drinking water (e.g., 0.550 g/mL for 90 days) [134] and as oral doses spanning from mg/kg/day regimens to very high bolus doses (e.g., up to 2000 mg/kg by gavage) [141]
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Expiry Date: 12/2027
