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DSIPs effects on the CRF pathway and cortisol regulation make it particularly relevant for stress-induced sleep problems

By deubiquitinating Sirt6, USP10 promotes the Nrf2/ARE signaling pathway, preserves renal function, and attenuates tubular epithelial cell injury and oxidative stress in mice[24]

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[7] [4] Neurological symptoms can occur even before anaemia develops and include paraesthesia (pins and needles) in the hands and feet, numbness, difficulty walking, and balance problems due to subacute combined degeneration of the spinal cord

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