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Under normal conditions, APAP is metabolized via conjugation with sulfate and glucuronide, leading to its excretion in the urine

92 High concentrations of lactate produced by aerobic glycolysis in HCC cells activates hydroxycarboxylic acid receptor 1 receptors on the plasma membrane and enhances monocarboxylate transporter 1-mediated lactate uptake, promotes ATP production, and deactivates the energy sensor, AMP-activated protein kinase (AMPK), resulting in upregulation of the expression of sterol regulatory element-binding protein 1 (SREBP1) and its target stearoyl-coenzyme A desaturase-1 (SCD1) to increase the production of anti-ferroptotic monounsaturated fatty acids