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Additionally, it has been reported that the mitochondria regulate the stemness of non-malignant stem cells, and that altering the mitochondrial function dictates the acquisition and maintenance of stemness of non-cancerous cells [ In vivo applications [ There are several approaches to target the mitochondria, which can be classified as molecule- and nanocarrier-based targeting

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PINK1 acts as a sensor of mitochondrial damage, Parkin acts as a signal amplifier, and ubiquitin chains act as signal effectors

10.1016/j.bbr.2024.115212 7 Alvarez-SanchezN.DunnS