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Description
Three relevant RCTs were extracted and assessed for validity, importance, and applicability
One carbon metabolism is a network of interrelated biochemical pathways that donate and regenerate one-carbon units, including the methyl group (reviewed [19,20])

10.1016/j.phymed.2020.153370 100 LuL.-Q.TianJ.LuoX.-J.PengJ

Benefits Visibly brighter and more uniform complexion
Such imbalances compromise synaptic plasticity, long-term potentiation and network stability in limbic regions (128)