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Description
ABCA1-mediated ApoE lipidation plays a key role in facilitating extracellular A degradation by IDE and facilitating A transport (Fan et al., 2009)
Drug Metab Dispos 2004
2022 Dec;45(6):1401-1419
Consequently, this competition heightens the likelihood of A aggregation in the brain, ultimately leading to plaque formation
The charged or polar nature of these residues attracts water molecules
