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[49] suggested that the upregulation of ICAM-1 could be reduced by an anti-ICAM-1 molecule, administered at the initial stage of the disease, thus preventing COPD exacerbations and its adverse outcomes [49, 50]

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Germain DL

Thus the primary effect of the inhibition is to prevent excess accumulation of GSH

This indicates a substantial growth in global interest regarding the influence of OS on DKD and stresses the essential need to investigate the pathogenic mechanisms of DKD from the molecular viewpoint of OS