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[64] Uniquely, Pitolisant has a novel mechanism of action as an H3 antagonists, which promotes the release of the wakefulness-promoting molecule amine histamine

Embo J 19:19871997 Moriguchi T, Hamada M, Morito N, Terunuma T, Hasegawa K, Zhang C, Yokomizo T, Esaki R, Kuroda E, Yoh K, Kudo T, Nagata M, Greaves DR, Engel JD, Yamamoto M, Takahashi S (2006) MafB is essential for renal development and F4/80 expression in macrophages

Regardless of the degradation pathway, no other impact on protein synthesis of skeletal muscle was found [33]

But regarding the safety issues, only a few are in consideration (Rubin et al., 2001)