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The quantification of Gems was represented as the average Gem numbers per cell in each cell line with three biological replicates

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Excess ROS acts on the nucleus, leading to increased mRNA expression of genes related to gluconeogenesis and cholesterol synthesis, glucose transporter type 2 (Glut2), glucokinase (GK), and sterol regulatory element-binding protein (SREBP)-2, 3-hydroxy-3-methylglutaryl coenzyme A reductase (HMGCR), and an increase in mitochondrial glucose uptake and acetyl coenzyme A production

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