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The first amino acid (3 eq.) and DIC (1.1 eq.) was dissolved in a minimum amount of DCM:DMF (4:1 v / v ) and added to the linker on resin followed by a drop wise addition of a catalytic amount of 4-dimethylaminopyridine (DMAP) (0.16 mmol), which was dissolved in DCM and then agitated for 2 h

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Together, these actions accelerate wound healing, improve tissue strength and elasticity, and support homeostatic recovery following injury or inflammation 1,5