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Indeed, their deregulations have a direct impact on nutrients uptake, gut functionality, and microbiome, and, importantly, pancreatic enzymes alterations are directly associated to adipose tissue wasting, making it an early event in pancreatic cancer-associated cachexia (Danai et al., 2018)
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Journal of Pharmacology and Experimental Therapeutics 308: 1138-1147.CrossRefGoogle ScholarPubMed HOPPEL, C

Complications of Carnitine Deficiency Syndrome include organ damage to the liver, heart, brain, and various skeletal muscles of the body, including heart muscle weakness (cardiomyopathy) Brain injury may present severe brain dysfunction (encephalopathy), irreversible learning problems, and mental retardation Another complication includes problems with the metabolism of the body, especially relating to fat and energy metabolism

doi: 10.1023/A:1024433100257
