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Description
However, it should be taken into account that although the difference in the pKa values of the two acidic groups of 4-hydroxythalidomide is sufficient to ensure selective alkylation of the phenolic group, a reaction may still occur in the imide nitrogen zone given its adequately acidity
O'Sullivan, E
Its presence helps the formula flow properly for consistent dosing
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Pharmacol Rev 40 163187 (1988)
