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This physical deconditioning accelerates muscle atrophy, creating a vicious cycle: the less muscle mass a patient has, the more exhausting simple physical tasks become, leading to further inactivity and further muscle loss

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The siliques of mdar1-2 (+/) mdar4-5 (/) double mutants have both normal and empty seeds, whereas those of the wild type and single mutants have only normal seeds, suggesting that the double knockout of both isoforms causes embryonic lethality (Tanaka et al

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Most well-designed research protocols use a 4-week-on/4-week-off cycling schedule

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