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Abstract Acetaminophen (APAP) is a well-known analgesic and antipyretic drug

Specific correlation patterns between key genes and metabolites were identified: Camp, Ngp, Elane, and Mop showed positive correlations between quercetin 3-glucuronide, xanthine, dihydro isorescinnamine, cortisol, pralatrexate, and inosine, but they showed negative correlations between L-dopa, acrylamide, and N-cinnamylglycine (Figures 10AE)

We erred on the side of lower passive absorption for children and decided not to recommend doses less frequently than once per day for children up to 3 years of age

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