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It was found that the spermatogenic impairment could be induced by decreasing expression of c-kit, as a survival factor, in spermatogonia or enhancing CK18, as a death factor, in Sertoli cells (42, 44-50)

However, etiologic factors that lead to chronic liver diseases (CLDs), such as alcohol-related liver disease, nonalcoholic fatty liver disease, viral hepatitis, and primary biliary cholangitis, can all affect the brain through mechanisms independent of liver failure/dysfunction triggering [44,45,46,47]

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Human Reprod 20(4):10061012 Geva E, Bartoov B, Zabludovsky N, Lessing JB, Lerner-Geva L, Amit A (1996) The effect of antioxidant treatment on human spermatozoa and fertilization rate in an in vitro fertilization program

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