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Description
Research reveals that senescent cells show upregulation of pro-apoptotic initiators PUMA and BIM while anti-apoptotic guardian BCL-2 is reduced, suggesting these cells are ready to undergo apoptosis but the execution is restrained by the FOXO4-p53 interaction
Then further maintenance doses every 4,6 or 12 weeks

Malmir M, Naderi Noreini S, Ghafarizadeh A, Faraji T, Asali Z

Stephen Chan, Sten Nilsson, Nicholas Blagden

doi: 10.1159/000199470
