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The incidence of fatigue, cognitive impairment, insomnia, joint pain and numbness in chronic LD is increased in some studies, while others report no difference from controls

Short-Term Response Some patients report noticing initial changes in comfort and function within weeks of beginning treatment, though individual experiences vary

Opioids: Heroin ( TABLE 1 The recreational abuse of six addictive drugs: mechanisms, clinical manifestations, and treatment

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