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CAFs increase the expression of branched-chain amino acid transaminase 1 (BCAT1) under the influence of cancer cells, and the subsequent increase in the breakdown of BCAAs provides a large amount of the metabolic product branched-chain -ketoacid (BCKA) for cancer cells to maintain de novo protein synthesis and the TCA cycle [330]

By helping transport fat into the mitochondria, they provide a sustained energy source, reduce the buildup of lactic acid, and support cardiovascular health by keeping the hearta fat-hungry musclewell-fuelled

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[DOI] [PMC free article] [PubMed] [Google Scholar] 26.Finney-Brown T

Within these pathways, many cell cytokines, including those associated with inflammation, such as IL-1, IL-6, TNF-10, IL-22, and TNF-alpha, contribute to the anorexia of cancer patients [8, 9, 12]