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This NAD + deficit directly impairs sirtuin activity (SIRT), compromising their regulation of mitochondrial biogenesis via PGC-1, antioxidant defense through FOXO transcription factors, and metabolic adaptation via HIF-1 modulation [106, 107]

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The time spent exploring each object was recorded

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It also contributes to nitrogen balance and efficient energy generation by converting BCAAs into their respective keto acids

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Physiological and metabolic changes during the transition from hyperthyroidism to euthyroidism in Graves' disease

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Neuroscience 424:2433

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