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Further, NAPQI is conjugated with glutathione to form acetaminophen-glutathione conjugate (APAP-SG) causing a significant glutathione depletion and oxidative stress leading to cell impairment or death (Jaeschke and Bajt 2006

Cells were fixed with 4% PFA, permeabilized with PBS (0.5% Triton-X) and stained overnight at 4C using the serum of a CL patient (SE6209/13) with high antibody titer against L

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schrenckii) induced by Aeromonas hydrophi la infection

In fact the interspecies variability in N -glucuronidation is particularly high, especially for aliphatic tertiary amines and, relevant to the LEO drug compound, aromatic N -heterocycles