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The long-term OS and PFS benefits of T1 in LC patients have been confirmed, and T1 also has the potential to reduce complications, restore immune function, and improve quality of life in the short term after surgery, so future clinical studies are needed to determine whether T1 can be used postoperatively to further enhance the effect of ERAS

Targeting cGAS-STING-dependent immune signaling pathway has been proved to be an effective strategy to enhance anti-cancer immunity and sensitive tumors to ICBs therapy [47]