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This physical mixture was processed in OMICRON 10 PHARMA co-rotating twin-screw extruder (Steer Engineering, Bangalore, India) with a 1.71-mm screw diameter at 105 RPM

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Concerning the molecular mechanisms implicated in HGF angiogenic role, there is a strong association with the E-twenty-six (Ets) pathway, which is implicated in the regulation of developmental and mitogen signals (Tomita et al., 2003)