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They cannot address what is happening at a cellular level where real skin ageing begins

doi: 10.1056/NEJMoa2112431 47 GotoKGotoYKuboTNinomiyaKKimSWPlanchardDet al

There is no conflict between the two

Jin Y, 2021, 'Modular immune-homeostatic microparticles promote immune tolerance in mouse autoimmune models', Science Translational Medicine , 13, pp
What matters most is dosage, form, and consistency