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3) leading to the discovery of PLGA as a material with customizable properties through varying the lactic-to-glycolic acid ratio 105,106

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The SIRT3 knockout mice are susceptible to hyperacetylated mitochondrial proteins and severe renal fibrosis, whereas honokiol restores the SIRT3 expression to alleviate fibrosis in a UUO-induced renal fibrosis mice model

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For instance, -asarone from Acori Tatarinowii Rhizoma has been formulated into chitosan nanoparticles to deliver astragaloside IV, improving nose-to-brain targeting and overcoming poor permeability and low lipophilicity [27]