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By crossing the blood-brain barrier, it participates in supporting the synthesis of neurotransmitters involved in memory and attention, supplying energy to neurons and maintaining the normal functioning of neural networks

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Figure 3 6.1 TMAO and cardiovascular disease Elevated circulating TMAO is strongly linked to cardiovascular and cerebrovascular diseases

LCMS/MS was carried out on an UltiMate 3000 nanoLC coupled to a Q Exactive Plus Orbitrap (Thermo Fisher Scientific) using aqueous and acetonitrile mobile phases, each supplemented with 0.1% formic acid