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AMPK activation, in turn, suppresses ferroptosis by inhibiting PUFA biosynthesis through phosphorylation of acetyl-CoA carboxylase 109
C.ChmielJ
By maintaining the intracellular pool of cysteine, system x c - activity is a key node preventing the onset of ferroptosis in many cells
NRF2 is anchored in the cytoplasm under normal conditions but enters the nucleus and activates antioxidant genes during oxidative stress [28, 29]
139 Moreover, ZIP10 is essential for zinc homeostasis within macrophages, where zinc is involved in antimicrobial responses
