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Some patients will respond to 10% parenteral amino acid solutions (Aminosyn, Abbott Laboratories, Chicago) given at a dose of 500 mL over 8 to 12 hours intravenously through a large-bore central venous catheter
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Recent work showed that hypoxia upregulated xCT SLC7A11 expression and increased intracellular cystine levels and GSH synthesis in multiple types of cancer cells (62, 82)
Notably, the NOX4 CA and AA genotype of rs3017887 exhibited a significant association with ALT levels
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