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Cerebral small vessel disease, the most prevalent cerebrovascular pathology, disrupts the myelin integrity of white matter through white matter hyperintensities (WMH), lacunar infarcts, and microbleeds, interfering with information transmission along white matter tracts [35]

Clinical translation would require trials in cardiac patient populations with appropriate safety monitoring given theoretical concerns about blood pressure effects and vascular remodeling

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Our laboratory is exploring the biological activities and particularly the ventilatory actions of the ethyl and methyl ester derivatives of these thiols against OIRD and as mentioned, we have determined that L-CYSee can elicit immediate reversal of the negative effects of morphine on ABG in anesthetized, tracheotomized rats but it is important to note that L-CYSee was not effective in rats without a tracheotomy, obviously suggesting that L-CYSee had negative effects in the upper airway and that better thiolester therapeutics than L-CYSee need to be considered