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Psoriasis-like skin disease and arthritis caused by inducible epidermal deletion of Jun proteins

Genome-wide CRISPR activation screening identified guanosine triphosphate cyclohydrolase 1 (GCH1), the rate-limiting enzyme in the synthesis of BH 4 , as a potent GPX4-independent ferroptosis-inhibiting factor
615 Beyond these compounds, novel inhibitors have been introduced

Evening administration is as pharmacologically neutral as morning dosing