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Acknowledgements We would like to thank Veronika Gurianova and Anna Brattseva for their kind support

For both assays, transcriptional activity was quantified by measuring secreted Gaussia luciferase signals in the culture supernatant using the Secrete-Pair Dual Luminescence Assay Kit (GeneCopoeia) according to the manufacturers instructions

A clinical trial is evaluating the effectiveness of niacin or niacinamide supplementation on inflammation and severity of PD symptoms (167)

2015;10(7):e0133153

Anyone with hormonal conditions or pineal gland issues should specifically consult with a qualified practitioner, as the pineal gland is hormonally active and plays important regulatory roles
