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-AR Desensitization/Down-Regulation and RyR2 Dysfunction/Ca 2+ Leak Are Two Distinct Yet Related Abnormalities in HF In HF cardiomyocytes develop 2 distinct yet related abnormalities: -AR desensitization/down-regulation and RyR2 dysfunction/Ca 2+ leak (Figure 1)
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It can also be a symptom of head injury, stroke, or brain inflammation
