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In a randomized, double-blind, placebo-controlled trial published in The Lancet, obese patients receiving Tesofensine experienced substantially greater weight reductions compared to those on a placebo

This pathway is critical to maintain the key molecule antioxidant glutathione (GSH) in a reduced state, regulating oxidative stress levels (Fig
2010;285(52):40699-40705.[DOI] 162

Because the GPX4 enzyme (which relies heavily on active glutathione to protect cell membranes) is impaired, the excess ROS molecules begin attacking the lipids that form the mitochondrial membranes

Many studies used glutamine-containing dipeptides, which might affect the discrepancy of outcomes