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ACSL4 is widely expressed in brain tissue, especially in the hippocampal CA1 region, and the expression of ACSL4 is gradually increased during cerebral ischemia (Kassan et al., 2013

Bacterial strains were either grown in LB medium or M9 minimal medium containing 8.5 g/l Na 2 HPO 4 2H 2 O, 3 g/l KH 2 PO 4 , 0.5 g/l NaCl, 1 g/l NH 4 Cl, 2 mM MgCl 2 , 100 M CaCl 2 supplemented with trace elements (0.1 mM EDTA, 0.03 mM FeCl 3 , 6.2 M ZnCl 2 , 0.76 M CuCl 2 , 0.42 M CoCl 2 , 1.62 M H 3 BO 3

In case of autoimmune components, auto-antibodies directed at fetal brain proteins might cause BBB damage (Zimmerman et al., 2007)

J Clin Endocrinol Metab (2011) 96(6):185963

Such dysfunction leads to altered mitochondrial dynamics, impairment of the mitochondrial electron transport chain, increased ROS production, and consequently exacerbates OS [61]