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However, there are no completed large-scale human clinical trials

Indeed, some studies have shown that collagen hydrolysate can boost the synthesis of collagen by skin fibroblasts

Forman HJ, Zhang H, Rinna A. Glutathione: overview of its protective roles, measurement, and biosynthesis. Mol Aspects Med. 2009;30(1-2):1-12. doi:10.1016/j.mam.2008.08.006

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The selection was focused on the evidence of involvement of oxidative stress in their aetiology because of an overproduction of reactive oxygen species (ROS) due to metabolic conditions of the diseases or by a CoQ 10 deficiency associated with the disease