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However, this central assumption has been shown to be a major oversimplification (318)

When the synthesis of GSH synthesis is blocked, the activity of GPX4 is decreased, as is the cellular antioxidant capacity, which leads to the accumulation of ROS and promotes ferroptosis (39)

Semin Pediatr Neurol (2013) 20(3):18893.10.1016/j.spen.2013.09.002 31 DongXGuanXChenKJinSWangCYanLet alAbnormal mitochondrial dynamics and impaired mitochondrial biogenesis in trigeminal ganglion neurons in a rat model of migraine

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