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Liu Q, Li S, Quan H, Li J

Damaged nerves can disrupt the signals controlling blood vessels, leading to reduced blood flow and circulation to certain areas

recommended storage below -18C desiccated, with reconstituted solutions viable at 4C for 27 days

doi: 10.1073/pnas.0307823100

Individuals with a personal history of acnewhether during adolescence or adulthoodmay theoretically be more susceptible, as their skin may already have a propensity towards follicular inflammation and altered sebaceous gland activity
