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This approach leads to selective oligodendrocyte stress and death, resulting in acute demyelination of distinct brain subregions, extensive microglial activation and astrocytic proliferation, a breakdown of the axonal transport mechanisms (Rhling, 2019), and, in more chronic models, overt axonal damage (Lindner, 2009)

380056) from 6 to 18 weeks of age, and co-housed with counterparts on the same diet, were purchased from The Jackson Laboratory (Bar Harbor, ME, USA)