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Recognizing these signs helps optimize your approach
Anyone with these conditions should obtain explicit medical clearance before receiving a B12 injection
Theriogenology 86 , 14531459 (2016)
Takahama U (2004) Oxidation of vacuolar and apoplastic phenolic substrates by peroxidase: physiological significance of the oxidation reactions

Most evidence comes from animal/in vitro studies, and human data is largely anecdotal from user reports, forums, and limited retrospective reviews