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Parkinson disease and the risk of epileptic seizures

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One mechanism by which ferritin is degraded upon depletion of free iron pools is ferritinophagy, a type of selective autophagy (Mancias et al, 2015) wherein select cellular components are recognized by an autophagy receptor protein and encapsulated in a double-membraned vesicle that is targeted to the lysosome for proteolysis (Zaffagnini & Martens, 2016)

For the GP, navigating the wide range of possible explanations for Alices symptoms was the first stage on the journey from symptom evaluation to considering possible diagnoses