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The review concluded that NNMT plays important roles in obesity and type 2 diabetes and validated 5-Amino-1MQ as a potent small-molecule NNMT inhibitor that reverses diet-induced metabolic changes, establishing it as a primary research tool for the NNMT pathway

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Combining both agents could theoretically amplify appetite suppression and gastrointestinal effects, though long-term safety data on this specific combination is lacking
