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Other therapeutic approaches outlined below include systemically decreasing cysteine levels and inhibiting GPX4

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It can also catalyze the reverse reaction and reduce the ketone into the corresponding hydroxy in the presence of NADH

PMC Article PMC4838773

Biosci Biotechnol Biochem 84(8):16211628 Liu J, He H, Wang J, Guo X, Lin H, Chen H, Jiang C et al (2020b) Oxidative stress-dependent frataxin inhibition mediated alcoholic hepatocytotoxicity through ferroptosis